Alcohol should not be taken with Circadin, because it reduces the effectiveness of Circadin on sleep. The prolonged release characteristics of Circadin may be altered by alcohol, resulting in immediate release of melatonin.

Circadin may enhance the sedative properties of benzodiazepines and non-benzodiazepine hypnotics (Z-drugs). In a clinical trial, there was clear evidence for a transitory pharmacodynamic interaction between Circadin and Zolpidem one hour following co-dosing. Concomitant administration resulted in increased impairment of attention, memory and coordination compared to zolpidem alone.

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