Rosuvastatin is a moderate-high intensity statin while Simvastatin is a low-moderate intensity statin. This means that Rosuvastatin can result in significantly greater reductions in LDL levels at lower dosages compared to Simvastatin.
Rosuvastatin is long-acting, it stays in the body longer than Simvastatin. Rosuvastatin can be taken any time of the day, however, it is preferable to take Simvastatin in the evening for best results.
In terms of safety, there are no significant differences in the side effect profiles. However, Simvastatin is more likely to have interactions with other medications and food compared to Rosuvastatin. Always inform a pharmacist or your doctor about all medications, supplements or health products you are taking.