The Day Starts with Sleep – Sleep Clinic in Singapore

Is your mind still running at 3 am? Don’t let your sleep problems affect your quality of life. Get online doctor’s advice and personalised treatment to improve sleep quality so you wake up feeling great!

We will ask some questions about your symptoms and health to see if treatment is right for you

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A sleep deprived nation

Sleep troubles are more common than you think. And the effects of sleep deprivation often lead to an unhealthy lifestyle


6 out of 10 Singaporeans experience poor sleep

sleep mask


Difficulty falling asleep due to stressful events, work problems, adjustments to changes, unhealthy habits



Not getting enough sleep due to irregular work hours, busy lifestyles, excessive screen time, irregular sleep routine



Difficulty staying asleep, waking up too early or in the middle of sleep, reduced morning alertness, feeling tired



Needs to reset the body clock due to frequent travelling, jet-lag symptoms


Sleep brings out the best

Sleep is the foundation of our every day. When you begin the day right, it improves your mental and emotional strength. It also have benefits to your general health, even your sex life.

What is Melatonin?

sleeping pills

Melatonin is a naturally occurring hormone that encourages sleep. It has been found that the level of melatonin in the body reduces with advancing age and in some medical conditions.

Taking melatonin supplements adds to your body’s natural supply of the hormone. This can help you get to sleep and improve the quality of your sleep when taken appropriately.

Benefits of SIRE Melatonin

ComparisonMelatonin (SIRE)Sleeping Pills
Types of treatmentNight2 Spray, Circadin 2mgXanax, Zopiclone, Zoloft
Increase sleep time and improves sleep quality
No “Hangover effects” – drowsiness, diminished alertness
No addictive potential / tolerance, rebound or withdrawal effect
Recommended for useUp to 13 weeksNot to be used more than 2-4 weeks

Treatment plan

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Customers must obtain a prescription from our doctors via the online consultation before they can receive the medicines.




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Prescription-grade melatonin



Prolonged-release melatonin treatment improves sleep quality, so you wake up refreshed and ready for the next day.


Night² Sleep Spray
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Supplement melatonin



Fast-acting drug-free treatment to help you fall asleep quickly, 2 sprays under the tongue before you go to bed.

Fast acting Melatonin
Night² Spray
Available only at SIRE

sleep spray

Choosing your Melatonin



Reset your sleep

  • Effective in clinical studies
  • Prescription-grade melatonin
  • Prolonged release to mimic body’s natural profile
  • Non-addictive ingredients
  • Established safety and efficacy
  • Quality guaranteed

Night² Spray

sleep spray

Fall asleep faster

  • Doctor-approved treatment
  • HSA-approved source
  • Fast-acting
  • Non-addictive ingredients
  • No need to swallow tablets
  • Prescription not required

Melatonin you can trust

Actual melatonin content in OTC (over-the-counter) products can vary from -83% to +478% of the claimed content

At Sire, the quality of our melatonin products are guaranteed!


Sleep well, live better

Adults surveyed who report having good quality sleep are happier and more optimistic

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The logos featured on this website are the copyrighted and registered trademarks of their respective owners.
All trademarks and names are used for demonstration purposes only and do not imply endorsement.

What is Insomnia?

Insomnia is defined as difficulty falling asleep, difficulty staying asleep, or waking up early in the morning and not being able to fall back to sleep.

In general, people with insomnia sleep less or sleep poorly despite having an adequate chance to sleep.

Sleeping poorly or not enough makes it harder to function during the daytime.


Multiple factors can contribute to poor sleep.

  •         Changes in sleeping environment (temperature, light, noise)
  •         Loss of loved one, divorce or job loss
  •         Recent medical illness, surgery or physical pain conditions
  •         Use of certain medications, supplements, herbal/traditional health products
  •         Frequent travels across multiple time zones
  •         Shift work
  •         Poor/irregular sleep habits
  •         Mental health problems like anxiety and depression

Can insomnia be treated?

Yes, however there is generally no quick fix for insomnia. It is important to identify and address the root causes of the insomnia. Here, at SIRE, we advocate building sleep resilience through various ways to protect our sleep.

The first-line treatment of insomnia often involves no medications and can be as effective as or even more effective than medications.

Multiple sleep research societies and guidelines endorse non-pharmacological or multi-component behavioural therapy to address insomnia.

Sleeping pills such as benzodiazepines (e.g. Xanax) and Z-drugs (e.g. Zolpidem and Zoloft) are recommended only for short-term treatment (generally less than 2-4 weeks) due to its addictive potential.

Here at SIRE, we believe good sleep can be cultivated through counseling and learning how to form good sleep habits. We also offer Melatonin, a supplement that is found to be effective and safe to get you through the difficult nights.

Find out more – “Are sleeping pills REALLY the answer for Singapore?”

Melatonin is a naturally occurring hormone that encourages sleep. It is produced by the pineal gland found in the brain.

The body produces melatonin just after it gets dark, with the highest levels of melatonin produced in the early hours of the morning (2-4 a.m.). Then, melatonin levels diminish in preparation for waking.

It has been found that the level of melatonin in the body reduces with advancing age and in some medical conditions.

Taking melatonin supplements adds to your body’s natural supply of the hormone. This can help you get to sleep and improve the quality of your sleep when taken appropriately.

Alcohol should not be taken with SIRE sleep products because it can reduce the effectiveness of melatonin. Alcohol before bedtime can also result in poorer sleep quality and cause sleep disruptions. 

SIRE sleep products may enhance the sedative effects of benzodiazepines (e.g. Xanax) and non-benzodiazepine hypnotics (Z-drugs e.g. Zolpidem, Zoloft). It is not advisable to stop sleeping pills abruptly on your own without a doctor’s advice, always speak to your doctor. 

Side effects of Melatonin are not well established with controlled studies. The most commonly reported side effects are vivid dreams and nightmares, dizziness, daytime sleepiness, headache, short-term feelings of depression, irritability, and stomach cramps.

Although long-term safety data of melatonin are not available, short-term studies suggest that it is relatively safe in most patient groups. Melatonin in supplement form is also only recommended for short-term usage.

It is always advisable to have a check with a doctor or pharmacist before starting on melatonin supplements, especially if you are on other long-term medications or underlying medical conditions.

The recommended dose is one to two sprays once daily. Always speak to your doctor for advice.


Yes, Circadin is a prescription-grade melatonin approved by HSA as a monotherapy for the short-term treatment of primary insomnia characterized by poor quality of sleep in patients who are aged 55 or over.

Night2 Sleep Spray:

No, Night2 Sleep Spray is a supplement used to promote healthy and quality sleep. Night2 Sleep Spray is obtained from HSA-approved sources. SIRE is a MOH-accredited telemedicine provider.


Yes, you can get a prescription for Circadin through a SIRE online visit for Sleep, if determined appropriate by our licensed physicians.

Night2 Sleep Spray

Yes, you can get Night2 Sleep Spray through SIRE online visit for Sleep, no consultation or prescription is required. If you need more help – our doctors at SIRE are here for you.

Melatonin is a supplement and is frequently used as a sleep aid. They help you fall asleep, improve sleep quality and increase sleep duration. However, they do not appear to be as effective as traditional sleeping pills like benzodiazepines and Z-drugs (e.g. Xanax and Zolpidem respectively).

Unlike traditional sleeping pills, melatonin has no addictive potential.

Refer to our Fair Medical Comparison between Melatonin and Traditional Sleeping Pills here

You can find many different types of melatonin supplements available in the form of chewables, liquids and pills. There are no available studies to compare the effectiveness of one form of melatonin supplement over another; the best form of melatonin supplement is mainly a matter of preference. 

Melatonin supplements available in the market can vary widely in their strength and accuracy as they do not undergo the same regulations as prescription medications. 

In Singapore, the HSA recommends buying health supplements from reliable sources such as a pharmacy or an established retail store. SIRE is a MOH registered telehealth provider, SIRE melatonin products are from HSA-approved sources.

Read our guide on How to Choose Melatonin in Singapore.

SIRE sleep products contain melatonin, they do not have addictive potential. They do not cause tolerance, rebound or withdrawal effects after taking it.


Circadin does not contain any animal ingredients. It does contain a small amount of lactose monohydrate, utilised in the formulation of Circadin.

Night2 Sleep Spray

All ingredients in Night2 Sleep Spray are plant-based and are not from animal origins.

Night2 Sleep Spray is not Halal-Certified. Night2 Sleep Spray is also an alcohol-free product.

Circadin is the first of a new class of drug for insomnia approved by HSA. Circadin has been used in multiple clinical trials, showing statistically significant and clinically meaningful efficacy in the treatment of insomnia.

Other melatonin supplements and preparations are not considered medicinal products and are not regulated by the health authorities. They have not been adequately tested in clinical controlled studies and there is no guarantee of their quality.

Circadin is registered with the HSA as a therapeutic product, this means that it is used for the treatment of insomnia as they have extensive clinical studies to support its efficacy and safety. As Circadin undergoes strict regulations by the HSA, its quality as a product is also guaranteed.

For other melatonin products, they are not extensively studied for their efficacy and safety and can only be used to promote and enhance sleep effects.

If you have more questions about Sleep, Melatonin, or our treatment options, please check out our FAQ section!

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