The Day Starts with Sleep
Is your mind still running at 3 am? Don’t let your sleep problems affect your quality of life. Get online doctor’s advice and personalised treatment to improve sleep quality so you wake up feeling great!
We will ask some questions about your symptoms and health to see if treatment is right for you
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A sleep deprived nation
Sleep troubles are more common than you think. And the effects of sleep deprivation often lead to an unhealthy lifestyle
Troubled
Sleeper
Difficulty falling asleep due to stressful events, work problems, adjustments to changes, unhealthy habits
Sleep
Deprived
Not getting enough sleep due to irregular work hours, busy lifestyles, excessive screen time, irregular sleep routine
Night
Owl
Difficulty staying asleep, waking up too early or in the middle of sleep, reduced morning alertness, feeling tired
Jet
Setter
Needs to reset the body clock due to frequent travelling, jet-lag symptoms
Sleep brings out the best
Sleep is the foundation of our every day. When you begin the day right, it improves your mental and emotional strength. It also have benefits to your general health, even your sex life.
What is Melatonin?
Melatonin is a naturally occurring hormone that encourages sleep. It has been found that the level of melatonin in the body reduces with advancing age and in some medical conditions.
Taking melatonin supplements adds to your body’s natural supply of the hormone. This can help you get to sleep and improve the quality of your sleep when taken appropriately.
Benefits of SIRE Melatonin
| Comparison | Melatonin (SIRE) | Sleeping Pills |
|---|---|---|
| Types of treatment | Night2 Spray, Circadin 2mg | Xanax, Zopiclone, Zoloft |
| Increase sleep time and improves sleep quality | ✅ | ✅ |
| No “Hangover effects” – drowsiness, diminished alertness | ✅ | ❌ |
| No addictive potential / tolerance, rebound or withdrawal effect | ✅ | ❌ |
| Recommended for use | Up to 13 weeks | Not to be used more than 2-4 weeks |
Treatment plan
Circadin
Prescription-grade melatonin
$4.10/night
from
Prolonged-release melatonin treatment improves sleep quality, so you wake up refreshed and ready for the next day.
Circadin 2mg
Circadin® 2mg
Important Safety Information
Circadin®
Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.
What does Circadin® contain?
The active ingredient in Circadin prolonged release tablets is melatonin.
Circadin prolonged release tablets also contain the excipients: ammonio methacrylate copolymer, calcium hydrogen phosphate, lactose, colloidal anhydrous silica, purified talc and magnesium stearate.
What is melatonin?
Melatonin is a naturally occurring hormone produced by the pineal gland and is structurally related to serotonin. Physiologically, melatonin secretion increases soon after the onset of darkness, peaks at 2-4 am and diminishes during the second half of the night. Melatonin is associated with the control of circadian rhythms and entrainment to the light-dark cycle. It is also associated with a hypnotic effect and increased propensity for sleep.
How does Circadin work?
Because of the role of melatonin in sleep and circadian rhythm regulation, and the age related decrease in endogenous melatonin production, melatonin may effectively improve sleep quality particularly in patients who are over 55 with primary insomnia.
How should I take Circadin?
Oral use. Tablets should be swallowed whole to maintain prolonged release properties. Crushing or chewing should not be used to facilitate swallowing. The recommended dose is 2 mg once daily, 1-2 hours before bedtime and after food. This dosage may be continued for up to thirteen weeks.
Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
Contraindications
Circadin prolonged release tablets are contraindicated in patients with a known hypersensitivity to any ingredient of the product (see WHAT DOES CIRCADIN CONTAIN?)
Precautions
Drowsiness
Circadin may cause drowsiness. Therefore the product should be used with caution if the effects of drowsiness are likely to be associated with a risk to safety.
Effects on ability to drive and operate machinery
Circadin has moderate influence on the ability to drive and use machines. Nevertheless, patients should avoid engaging in hazardous activities (such as driving or operating machinery) after taking Circadin.
Autoimmune diseases
No clinical data exist concerning the use of Circadin in individuals with autoimmune diseases. Therefore Circadin is not recommended for use in patients with autoimmune diseases.
Excipients
The tablets contain lactose. Patients with rare hereditary problems of galactose intolerance, the LAPP lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Effects on fertility
No significant effects on fertility or reproductive performance were observed in rats given oral melatonin prior to mating through to early gestation at doses over 900-fold the recommended clinical dose, based on body surface area.
Use in pregnancy
No clinical data on exposed pregnancies are available. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development. In view of the lack of clinical data, use in pregnant women and by women intending to become pregnant is not recommended.
Use in lactation
Endogenous melatonin was measured in human breast milk thus exogenous melatonin is probably secreted into human milk. There are data in animal models including rodents, sheep, bovine and primates that indicate maternal transfer of melatonin to the foetus via the placenta or in the milk. Therefore, breast-feeding is not recommended in women under treatment with melatonin.
Paediatric use
The safety and efficacy of Circadin in children aged 0 to 18 years has not yet been established. No data are available.
Use in the elderly
Melatonin metabolism is known to decline with age. Across a range of doses, higher AUC and Cmax levels have been reported in older subjects compared to younger subjects, reflecting the lower metabolism of melatonin in the elderly.
Renal insufficiency
The effect of any stage of renal insufficiency on melatonin pharmacokinetics has not been studied. Caution should be used when melatonin is administered to such patients.
Hepatic impairment
There is no experience of the use of Circadin in patients with liver impairment. Published data demonstrates markedly elevated endogenous melatonin levels during daytime hours due to decreased clearance in patients with hepatic impairment. Therefore, Circadin is not recommended for use in patients with hepatic impairment.
Carcinogenicity
An oral lifetime carcinogenicity study with melatonin in rats showed an increased incidence of thyroid follicular cell adenomas in males at doses around 700-fold the recommended clinical dose, based on body surface area. No neoplastic tissue histopathology was examined at lower doses and therefore the no-effect dose could not be determined. These effects were associated with liver enzyme induction in this species and are unlikely to be relevant to humans.
Genotoxicity
Results from a standard battery of in vitro and in vivo assays showed no evidence of a genotoxic potential for melatonin.
Interactions with other medicines
Tell your healthcare provider if you take any of the following because these drugs interact with Circadin.
Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure.
Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine.
Pharmacokinetic interactions
Hepatic enzymes
Melatonin has been observed to induce CYP3A in vitro at supra-therapeutic concentrations. The clinical relevance of the finding is unknown. If induction occurs, plasma concentrations of concomitantly administered drugs can be reduced.
Melatonin does not appear to induce CYP1A enzymes in vitro at supra[1]therapeutic concentrations. Therefore, interactions between melatonin and other active substances as a consequence of melatonin’s effect on CYP1A enzymes are not likely to be significant.
Melatonin’s metabolism is mainly mediated by CYP1A enzymes. Therefore, interactions between melatonin and other active substances as a consequence of their effect on CYP1A enzymes is possible:
Quinolones – CYP1A2 inhibitors such as quinolones may give rise to increased melatonin exposure.
Carbamazepine and rifampicin – CYP1A2 inducers such as carbamazepine and rifampicin may give rise to reduced plasma concentrations of melatonin.
Fluvoxamine – Caution should be exercised in patients on fluvoxamine, which increases melatonin levels (17-fold higher AUC and 12-fold higher serum Cmax) by inhibiting its metabolism by hepatic cytochrome P450 (CYP) isozymes CYP1A2 and CYP2C19. The combination should be avoided.
5- or 8-methoxypsoralen – Caution should be exercised in patients on 5- or 8- methoxypsoralen (5 and 8-MOP), which increases melatonin levels by inhibiting its metabolism.
Cimetidine – Coadministration of Circadin with cimetidine resulted in a 1.7 fold increase in exposure to melatonin with no change in the exposure to cimetidine. Caution should be exercised in patients on cimetidine, a CYP2D inhibitor which increases plasma melatonin levels by inhibiting its metabolism. Cigarette smoking – Cigarette smoking may decrease melatonin levels due to induction of CYP1A2. Oestrogens – Caution should be exercised in patients on oestrogens (e.g. contraceptives or hormone replacement therapy), which increase melatonin levels by inhibiting its metabolism by CYP1A1 and CYP1A2.
Other – There is a large amount of data in the literature regarding the effect of adrenergic agonists/antagonists, opiate agonists/antagonists, antidepressant medicinal products, prostaglandin inhibitors, benzodiazepines, tryptophan and alcohol, on endogenous melatonin secretion. Whether or not these active substances interfere with the dynamic or kinetic effects of Circadin or vice versa has not been studied.
Pharmacodynamic interactions
Alcohol
Alcohol should not be taken with Circadin, because it reduces the effectiveness of Circadin on sleep. The prolonged release characteristics of Circadin may be altered by alcohol, resulting in immediate release of melatonin.
Hypnotics
Circadin may enhance the sedative properties of benzodiazepines and non-benzodiazepine hypnotics, such as zalepon, zolpidem and zopiclone. In a clinical trial, there was clear evidence for a transitory pharmacodynamic interaction between Circadin and zolpidem one hour following co-dosing. Concomitant administration resulted in increased impairment of attention, memory and co-ordination compared to zolpidem alone.
Thioridazine and imipramine
Circadin has been co-administered in studies with thioridazine and imipramine, active substances which affect the central nervous system. No clinically significant pharmacokinetic interactions were found in each case. However, Circadin co-administration resulted in increased feelings of tranquility and difficulty in performing tasks compared to imipramine alone, and increased feelings of “muzzy-headedness” compared to thioridazine alone.
Effect on laboratory tests
No information is available on the effect of melatonin on laboratory tests.
Circadin Side Effects
The most common adverse reactions were headache, nasopharyngitis, back pain, and arthralgia, which were common, by MedDRA definition, in both the Circadin and placebo treated groups.
Tell your healthcare provider if you have any side effect that bothers you or does not go away.
These are not all the possible side effects of Circadin®. For more information, ask your healthcare provider or pharmacist, or see the full Prescribing Information for Circadin®.
Talk to your doctor for medical advice about side effects.
What happens if I overdose?
Several cases of overdose have been reported post-marketing. Somnolence was the most reported adverse event. Most were mild to moderate in severity.
If overdose occurs, drowsiness is to be expected. Clearance of the active substance is expected within 12 hours after ingestion.
Always check with a healthcare professional for advice.
Storage Conditions
Store below 25ºC. Protect from light
Popular questions
Is Circadin approved by HSA for use in sleep?
Yes, Circadin is a prescription-grade melatonin approved by HSA as a monotherapy for the short term treatment of primary insomnia characterized by poor quality of sleep in patients who are aged 55 or over.
Can I use Circadin with alcohol and/or other sleeping pills?
Alcohol should not be taken with Circadin, because it reduces the effectiveness of Circadin on sleep. The prolonged release characteristics of Circadin may be altered by alcohol, resulting in immediate release of melatonin.
Circadin may enhance the sedative properties of benzodiazepines and non-benzodiazepine hypnotics (Z-drugs). In a clinical trial, there was clear evidence for a transitory pharmacodynamic interaction between Circadin and Zolpidem one hour following co-dosing. Concomitant administration resulted in increased impairment of attention, memory and co-ordination compared to zolpidem alone.
Can I take Circadin more than once per day?
No, the recommended dose is one tablet (2mg) once daily.
Can I get a Circadin prescription online?
Yes, you can get a prescription through SIRE online visit for Sleep, if determined appropriate by our licensed physicians.
Night² Sleep Spray
Supplement melatonin
$39/bottle
from
Fast-acting drug-free treatment to help you fall asleep quickly, 2 sprays under the tongue before you go to bed.
Night2 Spray
Night2 Sleep Spray
Product and Safety Information
Disclaimer: The information provided on this page is not a substitute for professional medical advice, diagnosis, or treatment. If you have any questions or concerns about your health, please talk to a doctor.
What does Night2 Sleep Spray contain?
The active ingredient in Night2 Sleep Spray is melatonin. One spray of Night2 Sleep Spray (0.2mL of liquid) contains an equivalent of 0.3mg of melatonin. One bottle of Night2 Sleep Spray contains 12 mL of oral liquid.
Night2 Sleep Spray also contains the excipients: Stabiliser E473, Preservative E211, Sequestrant E386, Thickener E422, Pineapple Flavour, Humectant E1520, Sweetener E955, Ammonium Glycyrrhizate, Purified water
What is melatonin?
Melatonin belongs to a natural group of hormones produced by the pineal gland in the brain to control the sleep-wake cycles. The enzymes responsible for melatonin synthesis are activated and depressed by light and dark cycles. Release of melatonin follows a circadian rhythm generated by the suprachiasmatic nuclei in response to daylight alterations.
How does Night2 Sleep Spray work?
Night2 Sleep Spray is used to promote healthy and quality sleep.
When taken as a supplement, the function of melatonin is to mimic the effects of the natural hormone. Most of the actions of melatonin are mediated through the binding and activation of melatonin receptors.
Apart from regulating sleep-wake cycle it also plays a role in mood, learning and memory, immune activity, dreaming, fertility and reproduction. In addition, melatonin is also an effective antioxidant. Reduced melatonin production has also been proposed as a likely factor in the significantly higher cancer rates in night workers.
Features of Night2 Sleep Spray:
- Unlike currently available formulations Night2 Sleep Spray contain nanoparticles which show rapid gastric emptying thereby increasing rate of absorption
- The nanoparticles in Night2 Sleep Spray are unaffected by varying stomach and intestinal tract pH conditions
- The nanoparticles in Night2 Sleep Spray is unaffected by fed-fast variation hence predictable oral bioavailability
- Nano-encapsulation of melatonin in Night2 Sleep Spray improves stability of melatonin
- Nano-encapsulation of melatonin makes Night2 Sleep Spray highly palatable
How should I take Night2 Sleep Spray?
Oral use. One to two sprays to be taken daily before bedtime.
Otherwise, take this medicine exactly as how your doctor has told you. Check with your doctor or pharmacist if you are not sure.
Directions for use
- Remove the plastic cap (Fig. 1)
- Priming: hold the container upright. Point the black spray opening in a safe direction away from your face and other people. Fully press down on the pump with your forefinger. Release the pump and let the pump return to the starting position.
- Hold the container upright with forefinger on top of the grooved button (Fig 2)
- Open the mouth and bring the container as close to it as possible (Fig 3)
- Press the button firmly to make sure that a full dose of Night2 Sleep Spray is sprayed directly into your mouth under your tongue.
- Let the pump return to the starting position (for next dose repeat step 5&6)
- Close the bottle with cap (Fig 4)
- Avoid swallowing immediately after administering the spray
- Following administration don’t rinse mouth for 2-5 minutes
Do NOT inhale Night2 Sleep Spray
Contraindications
Night2 Sleep Spray is contraindicated in patients with a known hypersensitivity to any ingredient of the product (see WHAT DOES NIGHT2 SLEEP SPRAY CONTAIN?)
Precautions
Keep out of the reach of children.
Night2 Sleep Spray should be used with caution in patients suffering with renal impairment, bleeding disorders, depression, hypertension and seizure disorder.
Night2 Sleep Spray may increase blood sugar levels in patients with diabetes. It can also alter immune function in individuals on immunosuppressive therapies or those who have undergone transplants.
Drowsiness
Night2 Sleep Spray may cause drowsiness. Therefore the product should be used with caution if the effects of drowsiness are likely to be associated with a risk to safety.
Effects on ability to drive and operate machinery
Night2 Sleep Spray has moderate influence on the ability to drive and use machines. Nevertheless, patients should avoid engaging in hazardous activities (such as driving or operating machinery) after taking Night2 Sleep Spray.
Effects on fertility
No significant effects on fertility or reproductive performance were observed in rats given oral melatonin prior to mating through to early gestation at doses over 900-fold the recommended clinical dose, based on body surface area.
Use in pregnancy
No clinical data on exposed pregnancies are available. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnatal development. In view of the lack of clinical data, use in pregnant women and by women intending to become pregnant is not recommended.
Use in lactation
Endogenous melatonin was measured in human breast milk thus exogenous melatonin is probably secreted into human milk. There are data in animal models including rodents, sheep, bovine and primates that indicate maternal transfer of melatonin to the foetus via the placenta or in the milk. Therefore, breast-feeding is not recommended in women under treatment with melatonin.
Renal insufficiency
The effect of any stage of renal insufficiency on melatonin pharmacokinetics has not been studied. Caution should be used when melatonin is administered to such patients.
Hepatic impairment
Published data demonstrates markedly elevated endogenous melatonin levels during daytime hours due to decreased clearance in patients with hepatic impairment. Therefore, Night2 Sleep Spray is not recommended for use in patients with hepatic impairment.
Carcinogenicity
An oral lifetime carcinogenicity study with melatonin in rats showed an increased incidence of thyroid follicular cell adenomas in males at doses around 700-fold the recommended clinical dose, based on body surface area. No neoplastic tissue histopathology was examined at lower doses and therefore the no-effect dose could not be determined. These effects were associated with liver enzyme induction in this species and are unlikely to be relevant to humans.
Genotoxicity
Results from a standard battery of in vitro and in vivo assays showed no evidence of a genotoxic potential for melatonin.
Interactions with other medicines
Tell your healthcare provider if you take any of the following because these drugs may interact with Night2 Sleep Spray.
Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure.
Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine.
Pharmacokinetic interactions
Hepatic enzymes
Melatonin has been observed to induce CYP3A in vitro at supra-therapeutic concentrations. The clinical relevance of the finding is unknown. If induction occurs, plasma concentrations of concomitantly administered drugs can be reduced.
Melatonin does not appear to induce CYP1A enzymes in vitro at supra[1]therapeutic concentrations. Therefore, interactions between melatonin and other active substances as a consequence of melatonin’s effect on CYP1A enzymes are not likely to be significant.
Melatonin’s metabolism is mainly mediated by CYP1A enzymes. Therefore, interactions between melatonin and other active substances as a consequence of their effect on CYP1A enzymes is possible: Quinolones – CYP1A2 inhibitors such as quinolones may give rise to increased melatonin exposure. Carbamazepine and rifampicin – CYP1A2 inducers such as carbamazepine and rifampicin may give rise to reduced plasma concentrations of melatonin.
Fluvoxamine – Caution should be exercised in patients on fluvoxamine, which increases melatonin levels (17-fold higher AUC and 12-fold higher serum Cmax) by inhibiting its metabolism by hepatic cytochrome P450 (CYP) isozymes CYP1A2 and CYP2C19. The combination should be avoided.
5- or 8-methoxypsoralen – Caution should be exercised in patients on 5- or 8- methoxypsoralen (5 and 8-MOP), which increases melatonin levels by inhibiting its metabolism.
Cimetidine – Caution should be exercised in patients on cimetidine, a CYP2D inhibitor which increases plasma melatonin levels by inhibiting its metabolism.
Cigarette smoking – Cigarette smoking may decrease melatonin levels due to induction of CYP1A2. Oestrogens – Caution should be exercised in patients on oestrogens (e.g. contraceptives or hormone replacement therapy), which increase melatonin levels by inhibiting its metabolism by CYP1A1 and CYP1A2.
Other – There is a large amount of data in the literature regarding the effect of adrenergic agonists/antagonists, opiate agonists/antagonists, antidepressant medicinal products, prostaglandin inhibitors, benzodiazepines, tryptophan and alcohol, on endogenous melatonin secretion. Whether or not these active substances interfere with the dynamic or kinetic effects of Night2 Sleep Spray or vice versa has not been studied.
Night2 Sleep Spray Side Effects
The most common side effects include day-time drowsiness, headache and dizziness.
Tell your healthcare provider if you have any side effect that bothers you or does not go away.
These are not all the possible side effects of Night2 Sleep Spray. For more information, ask your healthcare provider or pharmacist.
Talk to your doctor for medical advice about side effects.
What happens if I overdose?
If overdose occurs, drowsiness is to be expected. Clearance of the active substance is expected within 12 hours after ingestion.
Always check with a healthcare professional for advice.
Storage Conditions
Store below 30ºC. Protect from direct sunlight
Popular questions
Is Night2 Sleep Spray approved by HSA for use in sleep?
No, Night2 Sleep Spray is a supplement used to promote healthy and quality sleep. Night2 Sleep Spray is obtained from HSA-approved sources. SIRE is a MOH-accredited telemedicine provider.
Can I use Night2 Sleep Spray with alcohol and/or other sleeping pills?
Alcohol should not be taken with Night2 Sleep Spray, because it reduces the effectiveness of Night2 Sleep Spray on sleep.
Night2 Sleep Spray may enhance the sedative properties of benzodiazepines and non-benzodiazepine hypnotics (Z-drugs). Always speak to your doctor for advice.
Can I take Night2 Sleep Spray more than once per day?
The recommended dose is one to two sprays once daily. Always speak to your doctor for advice.
Is Night2 Sleep Spray Halal-Certified and/or suitable for vegetarians?
All ingredients in Night2 Sleep Spray are plant-based and are not from animal origins.
Night2 Sleep Spray is also an alcohol-free product. Night2 Sleep Spray is not Halal-Certified.
Can I get Night2 Sleep Spray online?
Yes, you can get Night2 Sleep Spray through SIRE online visit for Sleep, no consultation or prescription is required. If you need more help – our doctors at SIRE are here for you.
Fast acting Melatonin
Night² Spray
Available only at SIRE
Choosing your Melatonin
Circadin
Reset your sleep
- Effective in clinical studies
- Prescription-grade melatonin
- Prolonged release to mimic body’s natural profile
- Non-addictive ingredients
- Established safety and efficacy
- Quality guaranteed
Night² Spray
Fall asleep faster
- Doctor-approved treatment
- HSA-approved source
- Fast-acting
- Non-addictive ingredients
- No need to swallow tablets
- Prescription not required
Melatonin you can trust
Actual melatonin content in OTC (over-the-counter) products can vary from -83% to +478% of the claimed content
At Sire, the quality of our melatonin products are guaranteed!
Sleep well, live better
Adults surveyed who report having good quality sleep are happier and more optimistic
What is Insomnia?
Insomnia is defined as difficulty falling asleep, difficulty staying asleep, or waking up early in the morning and not being able to fall back to sleep.
In general, people with insomnia sleep less or sleep poorly despite having an adequate chance to sleep.
Sleeping poorly or not enough makes it harder to function during the daytime.
COMMON QUESTIONS
Multiple factors can contribute to poor sleep.
- Changes in sleeping environment (temperature, light, noise)
- Loss of loved one, divorce or job loss
- Recent medical illness, surgery or physical pain conditions
- Use of certain medications, supplements, herbal/traditional health products
- Frequent travels across multiple time zones
- Shift work
- Poor/irregular sleep habits
- Mental health problems like anxiety and depression
Can insomnia be treated?
Yes, however there is generally no quick fix for insomnia. It is important to identify and address the root causes of the insomnia. Here, at SIRE, we advocate building sleep resilience through various ways to protect our sleep.
The first-line treatment of insomnia often involves no medications and can be as effective as or even more effective than medications.
Multiple sleep research societies and guidelines endorse non-pharmacological or multi-component behavioural therapy to address insomnia.
Sleeping pills such as benzodiazepines (e.g. Xanax) and Z-drugs (e.g. Zolpidem and Zoloft) are recommended only for short-term treatment (generally less than 2-4 weeks) due to its addictive potential.
Here at SIRE, we believe good sleep can be cultivated through counseling and learning how to form good sleep habits. We also offer Melatonin, a supplement that is found to be effective and safe to get you through the difficult nights.
Find out more – “Are sleeping pills REALLY the answer for Singapore?”
Melatonin is a naturally occurring hormone that encourages sleep. It is produced by the pineal gland found in the brain.
The body produces melatonin just after it gets dark, with the highest levels of melatonin produced in the early hours of the morning (2-4 a.m.). Then, melatonin levels diminish in preparation for waking.
It has been found that the level of melatonin in the body reduces with advancing age and in some medical conditions.
Taking melatonin supplements adds to your body’s natural supply of the hormone. This can help you get to sleep and improve the quality of your sleep when taken appropriately.
Alcohol should not be taken with SIRE sleep products because it can reduce the effectiveness of melatonin. Alcohol before bedtime can also result in poorer sleep quality and cause sleep disruptions.
SIRE sleep products may enhance the sedative effects of benzodiazepines (e.g. Xanax) and non-benzodiazepine hypnotics (Z-drugs e.g. Zolpidem, Zoloft). It is not advisable to stop sleeping pills abruptly on your own without a doctor’s advice, always speak to your doctor.
Side effects of Melatonin are not well established with controlled studies. The most commonly reported side effects are vivid dreams and nightmares, dizziness, daytime sleepiness, headache, short-term feelings of depression, irritability, and stomach cramps.
Although long-term safety data of melatonin are not available, short-term studies suggest that it is relatively safe in most patient groups. Melatonin in supplement form is also only recommended for short-term usage.
It is always advisable to have a check with a doctor or pharmacist before starting on melatonin supplements, especially if you are on other long-term medications or underlying medical conditions.
The recommended dose is one to two sprays once daily. Always speak to your doctor for advice.
Circadin:
Yes, Circadin is a prescription-grade melatonin approved by HSA as a monotherapy for the short-term treatment of primary insomnia characterized by poor quality of sleep in patients who are aged 55 or over.
Night2 Sleep Spray:
No, Night2 Sleep Spray is a supplement used to promote healthy and quality sleep. Night2 Sleep Spray is obtained from HSA-approved sources. SIRE is a MOH-accredited telemedicine provider.
Circadin:
Yes, you can get a prescription for Circadin through a SIRE online visit for Sleep, if determined appropriate by our licensed physicians.
Night2 Sleep Spray
Yes, you can get Night2 Sleep Spray through SIRE online visit for Sleep, no consultation or prescription is required. If you need more help – our doctors at SIRE are here for you.
Melatonin is a supplement and is frequently used as a sleep aid. They help you fall asleep, improve sleep quality and increase sleep duration. However, they do not appear to be as effective as traditional sleeping pills like benzodiazepines and Z-drugs (e.g. Xanax and Zolpidem respectively).
Unlike traditional sleeping pills, melatonin has no addictive potential.
Refer to our Fair Medical Comparison between Melatonin and Traditional Sleeping Pills here.
You can find many different types of melatonin supplements available in the form of chewables, liquids and pills. There are no available studies to compare the effectiveness of one form of melatonin supplement over another; the best form of melatonin supplement is mainly a matter of preference.
Melatonin supplements available in the market can vary widely in their strength and accuracy as they do not undergo the same regulations as prescription medications.
In Singapore, the HSA recommends buying health supplements from reliable sources such as a pharmacy or an established retail store. SIRE is a MOH registered telehealth provider, SIRE melatonin products are from HSA-approved sources.
Read our guide on How to Choose Melatonin in Singapore.
SIRE sleep products contain melatonin, they do not have addictive potential. They do not cause tolerance, rebound or withdrawal effects after taking it.
Circadin
Circadin does not contain any animal ingredients. It does contain a small amount of lactose monohydrate, utilised in the formulation of Circadin.
Night2 Sleep Spray
All ingredients in Night2 Sleep Spray are plant-based and are not from animal origins.
Night2 Sleep Spray is not Halal-Certified. Night2 Sleep Spray is also an alcohol-free product.
Circadin is the first of a new class of drug for insomnia approved by HSA. Circadin has been used in multiple clinical trials, showing statistically significant and clinically meaningful efficacy in the treatment of insomnia.
Other melatonin supplements and preparations are not considered medicinal products and are not regulated by the health authorities. They have not been adequately tested in clinical controlled studies and there is no guarantee of their quality.
Circadin is registered with the HSA as a therapeutic product, this means that it is used for the treatment of insomnia as they have extensive clinical studies to support its efficacy and safety. As Circadin undergoes strict regulations by the HSA, its quality as a product is also guaranteed.
For other melatonin products, they are not extensively studied for their efficacy and safety and can only be used to promote and enhance sleep effects.
If you have more questions about Sleep, Melatonin, or our treatment options, please check out our FAQ section!
