Sire’s Weight Management : Your Journey to a Healthier You

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Mounjaro, also known as Zepbound, is a new kid in the block. A weight loss injection that contains Tirzepatide, that is taken once a week, it works very similar to Saxenda or Wegovy. But what is the difference between the three, and can they be all used to lose weight? If you are curious about Saxenda / Wegovy, read here, to learn more on Tirzepatide and its alternatives, read on.

Alternatives to Zepbound/Mounjaro

We’ve helped countless customers in their successful weight loss journey. That being stated, we at Sire, keep a close eye on related medications and latest developments. Today, we’re diving into the buzz surrounding Tirzepatide, brand names Zepbound or Mounjaro is causing a stir as recent studies show promise in accelerating weight loss.

This has subsequently caused a surge in the manufacturer Eli Lilly’s stock price. While Tirzepatide might not be available in Asia until the end of 2024 or early 2025, we’re here to guide you through some compelling alternatives that you can consider right now.

Before we dive into the alternatives, let’s take a look at what Tirzepatide is and its role in helping people lose weight. Tirzepatide is a special substance in our bodies that helps with important functions. It acts like two kinds of hormones called Glucagon-like Peptide-1 (GLP-1) and Glucose-Dependent Insulinotropic Polypeptide (GIP). 

GLP-1 helps control digestion and appetite. Tirzepatide slows down stomach emptying, making you feel full longer, reduces cravings, and helps the pancreas release insulin while blocking sugar release from the liver. This leads to eating less and ultimately loss in weight. GIP supports GLP-1 in regulating appetite and digestion. 

Unlike other medications, Tirzepatide activates two receptors, GLP-1 and GIP, making it unique. A 72-week study found that heavier adults without diabetes achieved an average weight loss of 20.9% with tirzepatide

The Tirzepatide Frenzy

Tirzepatide, the new kid on the block, has created quite a stir in the weight loss community. With its promises of effective weight management, it’s no wonder that people are eager to get their hands on it. However, due to stock limitations, the availability of Tirzepatide in Asia remains uncertain for the time being.

Alternatives to Tirzepatide: Saxenda and Contrave

Tirzepatide alternatives for weight loss in Singapore

While we patiently wait for Tirzepatide to become available, it’s essential to explore alternative options that are readily accessible. Two notable contenders in the weight loss medication arena are Saxenda and Contrave.

Saxenda – The Daily Ally

Saxenda, like Tirzepatide, belongs to the GLP-1 receptor agonist class. It has shown promising results in aiding weight loss and improving overall health. Administered as a daily injection, as clinical trials indicate, Saxenda is a convenient and promising choice for those looking for consistent support on their weight loss journey.

Saxenda mimics the action of the natural incretin hormone GLP-1, regulating blood sugar levels, stimulating insulin release, and reducing appetite. Clinical trials have demonstrated that Saxenda, in combination with lifestyle interventions, can lead to a significant reduction in body weight.

Contrave – A Unique Combination

Contrave, on the other hand,  research suggests that it stands out as a combination of Bupropion and Naltrexone. This unique blend addresses food cravings and increases feelings of fullness, making it a comprehensive solution for weight management. With a different mechanism from Tirzepatide, Contrave offers versatility in your weight loss approach.

Bupropion, an antidepressant, works on the brain’s appetite control center, reducing food cravings. Naltrexone, used in addiction treatment, complements Bupropion by enhancing feelings of fullness. This dual-action approach makes Contrave a powerful solution for those seeking effective weight management.

Panbesy and Duromine

In addition to Saxenda and Contrave, two other weight loss medications that have long been trusted by individuals striving for healthier lifestyles are Panbesy and Duromine.


Panbesy contains phentermine, a widely prescribed weight loss drug. It works by suppressing appetite and increasing metabolism, making it an effective choice for short-term weight management. 

Phentermine stimulates the hypothalamus gland in the brain, suppressing appetite and increasing metabolism. Clinical trials demonstrate a net weight loss of 7-8 kg with phentermine in short-term administration. 

Duromine – Time-Tested and Reliable:

Duromine, another phentermine-based medication, has stood the test of time. It’s a proven option for individuals with a BMI of 27 or higher, offering a targeted approach to weight loss. With its availability in capsule form, Duromine provides a convenient and straightforward solution.

Orlistat: Blocking Fat Absorption

In the world of weight loss medications, Orlistat supports weight loss by blocking the absorption of fat in the gut. Orlistat remains a reliable option for those seeking a long-term solution to weight management.

Orlistat inhibits the action of lipase, an enzyme responsible for breaking down fat in the digestive system. By blocking fat absorption, Orlistat helps individuals lose weight and maintain their progress over the long-term.

Clinical studies have shown its efficiency in facilitating weight loss, with an additional 3 kg of weight loss compared to a placebo after 12 months.

Whether it is Saxenda, Contrave, Panbesy or Duromine, you need a prescription to obtain them in Singapore.

This is where we can help at Sire, get your consultation online and the drugs delivered directly to your doorstep with a few clicks. We’ve helped many people through their weight loss journey and understand exactly what you need according to your age, lifestyle and health.

Hassle-free delivery ensures that you do not have to drive to busy pharmacies or medical centres. Get started here


As we eagerly await the arrival of Tirzepatide in Asia, it’s comforting to know that there are several alternatives ready to support your weight loss journey. From the daily injections of Saxenda to the unique combination in Contrave, and the established efficacy of Panbesy, Duromine, and Orlistat, there’s a diverse range of options to choose from.

Sire remains your trusted companion on this journey, offering insights and information to help you make informed decisions. Stay tuned for updates, explore the alternatives available, and help us help you achieve a healthier, happier lifestyle! 

For more comprehensive information on weight loss and related medication, read this guide.

Updated 29th January, 2023 

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